Jianbo YUE, co-founder of 6J Biotechnology, Chief Scientist.
Dr. Yue is a tenured professor of the Department of Biomedical Sciences, City University of Hong Kong. He is also a former Assistant Professor in the School of Medicine, the University of Hong Kong. Dr. Yue completed post-doc training in the School of Medicine, Stanford University. Dr. Yue obtained his Ph.D. degree from Pennsylvania State University. He received the Master degree from Peking University and Bachelor degree from Sichuan University, China. He has conducted pioneering research in the MAPK signaling pathway, mTOR/AKT signaling pathway, ROS, calcium signaling pathway, and screening small molecule for the therapy of cancer and other human diseases. His lab is one of the first groups to study calcium signaling and ROS on Autophagy in the world. He also established the cell models to measure cellular calcium, ROS, and Autophagy. He also firstly proved that the calcium released from the lysosome inhibited the fusion between autophagosomes and lysosomes, thus inhibiting Autophagy. His research group also recently demonstrated that oxidative stress activates calcium-regulated kinase II (CaMKII) by stimulating calcium influx to phosphorylate BECLIN1 and inhibit autophagy, making cells more susceptible to death. His group also developed a high-content fluorescence imaging platform to select a series of autophagy inhibitors and activators and also established the in vitro and in vivo systems to evaluate their functions (anti-cancer and viral infections). He has published multiple research papers with over 4100 citations. He also received over 20 million HKD research fundings as project leader.
